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Prednisolone

Brand Name :

Pred Forte®

Dosage form :

Ophthalmic suspension 1% (5 mL),tablet 5mg,20 mg.

Indication :

Treatment of palpebral and bulbar conjunctivitis; corneal injury from chemical, radiation, thermal
burns, or foreign body penetration; endocrine disorders, rheumatic disorders, collagen diseases, dermatologic diseases,
allergic states, ophthalmic diseases, respiratory diseases, hematologic disorders, neoplastic diseases, edematous states, and gastrointestinal diseases; resolution of acute exacerbations of multiple sclerosis; management of fulminating or disseminated tuberculosis and trichinosis; acute or chronic solid organ rejection

Dosage :

Dose depends upon condition being treated and response of patient; dosage for infants and children should be based on se-
verity of the disease and response of the patient rather than on strict adherence to dosage indicated by age, weight, or body
surface area. Oral dosage expressed in terms of prednisolone base. Consider alternate day therapy for long-term therapy.
Discontinuation of long-term therapy requires gradual withdrawal by tapering the dose. Patients undergoing unusual
stress while receiving corticosteroids, should receive increased doses prior to, during, and after the stressful situation.
Children: Dose ranges from 0.1 to 2 mg/kg/day in divided doses 1 to 4 times daily.
Adult: Oral: 5-60 mg daily. Multiple sclerosis (sodium phosphate): Oral: 200 mg daily for 1 week followed by 80 mg
every other day for 1 month. Rheumatoid arthritis: Oral: Initial: 5-7.5 mg daily; adjust dose as necessary.
Elderly: use lowest effective dose.

Ophthalmic suspension/solution: Conjunctivitis, corneal injury: Children and Adults: Instill 1-2 drops into conjunctival
sac every hour during day, every 2 hours at night until favorable response is obtained, then use 1 drop every 4 hours.
Elderly: Use lowest effective dose

Warning / precaution :

Adverse reactions :

Ophthalmic formulation:
Ocular: Conjunctival hyperemia, conjunctivitis, corneal ulcers, delayed wound healing, glaucoma, intraocular pressure
increased, keratitis, loss of accommodation, optic nerve damage, mydriasis, posterior subcapsular cataract formation,
ptosis, secondary ocular infection
Oral formulation:
Cardiovascular: Cardiomyopathy, CHF, edema, hypertension
Central Nervous System: Convulsions, headache, vertigo
Dermatologic: Bruising, facial erythema, hirsutism
Endocrine & metabolic: Carbohydrate tolerance decreased, Cushing’s syndrome, diabetes mellitus, growth suppression
Gastrointestinal: Abdominal distention, increased appetite, indigestion, nausea, pancreatitis, peptic ulcer
Neuromuscular & skeletal: Arthralgia, osteoporosis, steroid myopathy, tendon rupture, weakness Ocular: Cataracts,
exophthalmus, eyelid edema, glaucoma, intraocular pressure increased, irritation

Therapeutic class :

Medication safety issues :

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