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Brand Name :

(Lasix, Diusemide, Impugan) ®

Dosage form :

Tablet 40 mg, injection 20 mg/2 ml
IV, IM, 250 mg/25 ml IV infusion.

Indication :

Management of edema associated with congestive heart failure and
hepatic or renal disease; used alone or in combination with
antihypertensives in treatment of hypertension.

Dosage :

Infants and Children: Edema, heart failure:
Oral: Initial: 2 mg/kg/dose increased in increments of 1-2 mg/kg/dose
with each succeeding dose at intervals of 6-8 hours until a satisfactory
response is achieved; maximum dose: 6 mg/kg/dose.
I.M., I.V.: Initial: 1 mg/kg/dose; if response not adequate, may
increase dose in increments of 1 mg/kg/dose and administer not
sooner than 2 hours after previous dose, until a satisfactory response
is achieved; may administer maintenance dose at intervals of every 6-
12 hours; maximum dose: 6 mg/kg/dose.

Adults: Oral: 20-80 mg/dose initially increased in increments of 20 -
mg/dose at intervals of 6-8 hours; usual maintenance dose interval is
twice daily or every day; may be titrated up to 600 mg/day with
severe edematous states.
I.M., I.V.: 20-40 mg/dose, may be repeated in 1-2 hours as needed
and increased by 20 mg/dose until the desired effect has been
obtained; usual dosing interval: 6-12 hours; for acute pulmonary
edema, the usual dose is 40 mg over 1-2 minutes; if not adequate,
may increase dose to 80 mg.
Continuous I.V. infusion: Initial I.V. bolus dose of 0.1 mg/kg
followed by continuous I.V. infusion doses of 0.1 mg/kg/hour
doubled every 2 hours to a maximum of 0.4 mg/kg/hour if urine
output is <1 ml/kg/hour have been found to be effective and result in
a lower daily requirement of furosemide than with intermittent
dosing. Other studies have used a rate of ≤4 mg/minute as a
continuous I.V. infusion.

Elderly: Oral, I.M., I.V.: Initial: 20 mg/day; increase slowly to
desired response.
Refractory heart failure: Oral, I.V.: Doses up to 8 g/day have been

Warning / precaution :

Adverse reactions :

Orthostatic hypotension, thrombophlebitis, acute hypotension, sudden
death from cardiac arrest, virtigo, headache, blurred vision,
hyperglycemia, hyperuricemia, hypokalemia, hypochloremia,
metabolic alkalosis, hypocalcemia, hypomagnesemia, gout, urinary
bladder spasm, hearing impairment.

Therapeutic class :

Medication safety issues :

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